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Kidney Int. 2008 May;73(9):989-91. doi: 10.1038/ki.2008.104.

Role for alkaline phosphatase as an inducer of vascular calcification in renal failure?

Author information

1
Department of Internal Medicine and Cardiology, Philipps University, Marburg, Germany. schoppet@mailer.uni-marburg.de

Abstract

Vascular calcification is associated with increased cardiovascular morbidity and mortality. A number of calcification inhibitors have been defined recently, including inorganic pyrophosphate (PP(i)), an important physicochemical inhibitor of hydroxyapatite crystal growth. Increased hydrolysis of PP(i) by tissue-nonspecific alkaline phosphatase (TNAP) may occur in renal failure and act to enhance mineralization of vessels.

PMID:
18414436
DOI:
10.1038/ki.2008.104
[Indexed for MEDLINE]
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