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Mol Cells. 2008 Apr 30;25(2):242-6. Epub 2008 Mar 28.

Attenuated neuropathic pain in Cav3.1 null mice.

Author information

1
Center for Neural Science, Korea Institute of Science and Technology, Seoul 136-791, Korea.

Abstract

To assess the role of alpha(1G) T-type Ca2+ channels in neuropathic pain after L5 spinal nerve ligation, we examined behavioral pain susceptibility in mice lacking CaV3.1 (alpha1G(-/-)), the gene encoding the pore-forming units of these channels. Reduced spontaneous pain responses and an increased threshold for paw withdrawal in response to mechanical stimulation were observed in these mice. The alpha1G(-/-) mice also showed attenuated thermal hyperalgesia in response to both low-(IR30) and high-intensity (IR60) infrared stimulation. Our results reveal the importance of alpha(1G) T-type Ca2+ channels in the development of neuropathic pain, and suggest that selective modulation of alpha1G subtype channels may provide a novel approach to the treatment of allodynia and hyperalgesia.

PMID:
18414012
[Indexed for MEDLINE]
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