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Arch Neurol. 2008 Apr;65(4):540-4. doi: 10.1001/archneur.65.4.540.

Carbon 11-labeled pittsburgh compound B positron emission tomographic amyloid imaging in patients with APP locus duplication.

Author information

1
Clinical Research Centre, Oulu University Hospital, University of Oulu, Oulu, Finland. anne.remes@oulu.fi

Abstract

OBJECTIVE:

To investigate amyloid accumulation by carbon 11-labeled Pittsburgh Compound B (11C-PiB) in hereditary cerebral amyloid angiopathy and APP locus duplication.

DESIGN, SETTING, AND PATIENTS:

Positron emission tomography with 11C-PiB and magnetic resonance imaging were performed for 2 patients, 49-year-old and 60-year-old siblings with APP locus duplication, with hereditary Alzheimer disease and cerebral amyloid angiopathy.

MAIN OUTCOME MEASURE:

Change in 11C-PiB uptake.

RESULTS:

Uptake of 11C-PiB was increased especially in the striatum (caudate nucleus to 225% and 280% of the control mean and putamen to 166% and 185% of the control mean) and in the posterior cingulate (to 168% and 198% of the control mean), and it was marginally increased in other cortical brain areas. The pattern of increased 11C-PiB uptake was different from that seen in sporadic Alzheimer disease.

CONCLUSIONS:

Amyloid imaging with 11C-PiB positron emission tomography is a useful tool for detecting in vivo amyloid accumulation in patients with hereditary cerebral amyloid angiopathy. However, the pattern of 11C-PiB accumulation differs between patients with typical AD and patients with APP locus duplication.

PMID:
18413480
DOI:
10.1001/archneur.65.4.540
[Indexed for MEDLINE]

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