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Hum Brain Mapp. 2009 Apr;30(4):1060-7. doi: 10.1002/hbm.20566.

Nonrigid registration of multiple sclerosis brain images using lesion inpainting for morphometry or lesion mapping.

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Department of Neurology, University of California, San Francisco, 94107, USA.


Morphometric studies of medical images often include a nonrigid registration step from a subject to a common reference. The presence of white matter multiple sclerosis lesions will distort and bias the output of the registration. In this article, we present a method to remove this bias by filling such lesions to make the brain look like a healthy brain before the registration. We finally propose a dedicated method to fill the lesions and present numerical results showing that our method outperforms current state of the art method.

[Indexed for MEDLINE]

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