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BJOG. 2008 May;115(6):681-8. doi: 10.1111/j.1471-0528.2008.01701.x.

Maternal depression and medication exposure during pregnancy: comparison of maternal retrospective recall to prospective documentation.

Author information

1
Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, USA. jeff.newport@emory.edu

Abstract

OBJECTIVE:

Outcome investigations of prenatal maternal depression and psychotropic exposure rely extensively on maternal retrospective recall. This study compared postnatal recall to prospective documentation of illness and medication exposures.

DESIGN:

Prospective cohort and retrospective case-control studies.

SETTING:

Emory Women's Mental Health Program (prospective study) and Emory University Department of Psychology (retrospective study).

SAMPLE:

A total of 164 women who participated in both the prospective and retrospective studies.

METHODS:

Women with a history of mental illness were followed during pregnancy for prospective prenatal assessments of depression and medication exposures. At 6 months postpartum, some of these women also participated in a retrospective study during which they were asked to recall prenatal depression and medication use. Agreement between prospective and retrospective documentation of exposures was analysed.

MAIN OUTCOME MEASURES:

Occurrence of maternal depression during pregnancy and maternal use of pharmacological agents during pregnancy.

RESULTS:

There was only moderate agreement (k = 0.42) in prospective versus retrospective reporting of prenatal depression. Positive predictive value for recalling depression was 90.4%; however, negative predictive value for denying depression was only 53.8%. Participants accurately recalled psychotropic use but significantly underreported use of nonpsychotropic medications.

CONCLUSIONS:

Studies using retrospective data collection may be susceptible to systematic recall bias with underreporting of maternal depression and use of nonpsychotropic agents during pregnancy.

PMID:
18410650
PMCID:
PMC4714590
DOI:
10.1111/j.1471-0528.2008.01701.x
[Indexed for MEDLINE]
Free PMC Article

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