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Oral Dis. 2008 May;14(4):376-82. doi: 10.1111/j.1601-0825.2007.01395.x.

Fatty acid synthase expression in squamous cell carcinoma of the tongue: clinicopathological findings.

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1
Department of Oral Diagnosis, School of Dentistry of Piracicaba, University of Campinas (UNICAMP), São Paulo, Brazil.

Abstract

BACKGROUND:

Overexpression of fatty acid synthase (FAS), the cytosolic enzyme responsible for the conversion of dietary carbohydrates to fatty acids, has been reported in several human malignancies and pointed as a potential prognostic marker for some tumors. This study investigated whether FAS immunohistochemical expression is correlated with the clinicopathological characteristics of oral squamous cell carcinoma (OSCC).

MATERIALS AND METHODS:

The clinical features of 102 patients with OSCC of the tongue treated in a single institution were obtained from the medical records and all histopathological diagnoses were reviewed. The expression of FAS was determined by the standard immunoperoxidase technique in formalin-fixed and paraffin-embedded specimens and correlated with the clinicopathological characteristics of the tumors.

RESULTS:

Eighty-one cases (79.41%) were positive for FAS. Microscopic characteristics such as histological grade (P < 0.05), lymphatic permeation (P < 0.001), perineural infiltration (P < 0.05), and nodal metastasis (P < 0.02) were associated with FAS status. A significantly lower survival probability for patients with advanced clinical stage (log-rank test, P < 0.001), lymph nodes metastasis (log-rank test, P < 0.001), presence of vascular permeation (log-rank test, P = 0.05), and perineural invasion (log-rank test, P = 0.01) was observed in the studied samples.

CONCLUSION:

The expression of FAS in OSCC of the tongue is associated with the microscopic characteristics that determine disease progression and prognosis.

[Indexed for MEDLINE]

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