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J Am Chem Soc. 2008 May 7;130(18):5858-9. doi: 10.1021/ja800818b. Epub 2008 Apr 15.

Iron-catalyzed direct arylation through directed C-H bond activation.

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  • 1Department of Chemistry, University of Tokyo, Bunkyo-ku, Tokyo 113-0033, Japan.


An iron-catalyzed C-C bond formation reaction of a nitrogen-containing aromatic compound with an arylzinc reagent takes place at 0 degrees C in a good to quantitative yield. The reaction involves a C-H bond activation directed by a neighboring nitrogen atom. The important additives in this reaction are 1,10-phenanthroline, tetramethylethylenediamine, and 1,2-dichloro-2-methylpropane, in the absence of which a very low product yield was observed.

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