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Transplantation. 2008 Apr 15;85(7):923-7. doi: 10.1097/TP.0b013e3181683cf5.

Complement and renal transplantation: from donor to recipient.

Author information

1
Department of Surgery, University Medical Center Groningen, Groningen, The Netherlands. j.damman@chir.umcg.nl

Abstract

Long-term kidney graft survival is affected by different variables including donor condition, ischemia-reperfusion injury, and graft rejection during the transplantation process. The complement system is an important mediator of renal ischemia-reperfusion injury and in rejecting allografts. However, donor complement C3 seems to be crucial in renal transplantation-related injury as renal injury is attenuated in C3 deficient kidney grafts. Interestingly, before ischemia-reperfusion induced C3 expression, C3 is already induced in donors suffering from brain death. Therefore, strategies targeting complement activation in the brain-dead donor may increase graft viability and transplant outcome.

PMID:
18408568
DOI:
10.1097/TP.0b013e3181683cf5
[Indexed for MEDLINE]

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