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Trends Endocrinol Metab. 2008 Jul;19(5):161-6. doi: 10.1016/j.tem.2008.02.006. Epub 2008 Apr 11.

Reciprocal regulation of bone and energy metabolism.

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Department of Genetics and Development, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA.


The finding that fat regulates bone metabolism was viewed as an indication that bone might regulate some aspects of energy metabolism in a feedback loop. The search that started nine years ago for a bone-derived hormone that regulates energy metabolism first took a convoluted path through the identification of a modifier gene. Once this hormone, osteocalcin, was identified, it became clear that bone exerts a profound and complex influence on glucose and fat metabolism. This review highlights the most important salient features of this novel regulation of energy metabolism.

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