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Trends Endocrinol Metab. 2008 Aug;19(6):191-6. doi: 10.1016/j.tem.2008.03.001. Epub 2008 Apr 11.

Immune-like mechanisms in ovulation.

Author information

1
Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, USA. joanner@bcm.tmc.edu

Abstract

Ovulation is the unique biological process by which a mature oocyte (egg) and surrounding somatic cells, the cumulus cell-oocyte complex (COC), are released from the surface of the ovary into the oviduct for transport and fertilization. Ovulation is similar to an inflammatory response: the follicles become hyperemic, produce prostaglandins and synthesize a hyaluronan-rich extracellular matrix. However, this view of ovulation might be too restrictive and needs to be broadened to encompass the innate immune cell surveillance-response system. This hypothesis is being proposed because ovarian granulosa cells and cumulus cells express and respond to innate immune cell-related surveillance proteins (Toll-like receptors 2 and 4) and cytokines, such as interleukin 6 (IL-6), during ovulation.

PMID:
18407514
DOI:
10.1016/j.tem.2008.03.001
[Indexed for MEDLINE]
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