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Trends Endocrinol Metab. 1994 Jan-Feb;5(1):21-8.

Animal models of Cushing's disease.

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Robert J. Kemppainen is at the Department of Physiology and Pharmacology, College of Veterinary Medicine, Auburn University, Auburn, AL 36849, USA.


Cushing's disease, defined as hyperadrenocorticism resulting from excessive secretion of pituitary ACTH, occurs spontaneously and quite commonly in dogs and horses. In dogs, as in humans, the disease is usually associated with a small tumor of the pituitary pars distalis. However, the disease may arise occasionally (dogs) or exclusively (horses) from tumors or hyperplasia of the pituitary pars intermedia. In dogs, pars intermedia tumors may arise from one of two proopiomelanocortin-containing cell types that are present in normal tissue.


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