Format

Send to

Choose Destination
Trends Endocrinol Metab. 1994 Jan-Feb;5(1):21-8.

Animal models of Cushing's disease.

Author information

1
Robert J. Kemppainen is at the Department of Physiology and Pharmacology, College of Veterinary Medicine, Auburn University, Auburn, AL 36849, USA.

Abstract

Cushing's disease, defined as hyperadrenocorticism resulting from excessive secretion of pituitary ACTH, occurs spontaneously and quite commonly in dogs and horses. In dogs, as in humans, the disease is usually associated with a small tumor of the pituitary pars distalis. However, the disease may arise occasionally (dogs) or exclusively (horses) from tumors or hyperplasia of the pituitary pars intermedia. In dogs, pars intermedia tumors may arise from one of two proopiomelanocortin-containing cell types that are present in normal tissue.

PMID:
18407184

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center