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Trends Endocrinol Metab. 1993 Dec;4(10):309-14.

Receptors for secretin, calcitonin, parathyroid hormone (PTH)/PTH-related peptide, vasoactive intestinal peptide, glucagonlike peptide 1, growth hormone-releasing hormone, and glucagon belong to a newly discovered G-protein-linked receptor family.

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Endocrine Unit, Massachusetts General Hospital, USA; Department of Medicine, Harvard Medical School, USA; New England Deaconess Hospital, Boston, MA 02114, USA.


Seven receptors with highly homologous structural features have recently been discovered that belong to a new family of seven membrane-spanning receptors within the G-protein-linked receptor superfamily. These seven all bind small peptide ligands, and many have the unique property to activate the G(S) and at least one other G protein.

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