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Cell Host Microbe. 2008 Apr 17;3(4):206-12. doi: 10.1016/j.chom.2008.03.004.

P bodies, stress granules, and viral life cycles.

Author information

1
Department of Cell Biology and Anatomy, The University of Arizona, Tucson, AZ 85721-0206, USA.

Abstract

Eukaryotic mRNAs are in a dynamic equilibrium between different subcellular locations. Translating mRNAs can be found in polysomes, mRNAs stalled in translation initiation accumulate in stress granules and mRNAs targeted for degradation or translation repression can accumulate in P bodies. Partitioning of mRNAs between polysomes, stress granules, and P bodies affects rates of translation and mRNA degradation. Host proteins within P bodies and stress granules can enhance or limit viral infection, and some viral RNAs and proteins accumulate in P bodies and/or stress granules. Thus, an important interplay among P bodies, stress granules, and viral life cycles is beginning to emerge.

PMID:
18407064
PMCID:
PMC2396818
DOI:
10.1016/j.chom.2008.03.004
[Indexed for MEDLINE]
Free PMC Article

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