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Trends Biochem Sci. 2008 May;33(5):191-4. doi: 10.1016/j.tibs.2008.02.003. Epub 2008 Apr 9.

It takes a PHD to SUMO.

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1
Department of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, CA 94305, USA.

Abstract

PHD fingers and bromodomains are found in close proximity to each other in many chromatin-associated proteins and can functionally synergize. Recently, it has been demonstrated that the PHD finger of the KAP1 co-repressor functions as an E3 SUMO ligase for the adjacent bromodomain. This PHD-mediated SUMOylation stabilizes the association of the bromodomain with the chromatin modifiers SETDB1 and the nucleosome remodeling and deacetylation (NuRD) complex, thereby promoting establishment of the silent gene expression state.

PMID:
18406149
DOI:
10.1016/j.tibs.2008.02.003
[Indexed for MEDLINE]
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