Format

Send to

Choose Destination
See comment in PubMed Commons below
J Biol Chem. 1991 Dec 5;266(34):23416-21.

The hepatitis B virus S promoter comprises A CCAAT motif and two initiation regions.

Author information

1
Department of Pathology, Veterans Affairs Medical Center, San Francisco, California.

Abstract

The hepatitis B virus S (major surface gene) promoter is embedded in two overlapping open reading frames and specifies several transcripts with heterogeneous 5' termini. We have identified the cis-elements necessary for S promoter function. A single upstream CCAAT element is essential for high level expression in both liver and non-liver cells. No TATA box is present, but two regions surrounding the initiation sites can function separately as initiating elements. These results show that the S promoter has a simple requirement for upstream activating sequences, but a complex initiation region. Therefore, it may provide a suitable model system for studying transcription initiation in non-TATA type promoters.

PMID:
1840596
[Indexed for MEDLINE]
Free full text
PubMed Commons home

PubMed Commons

0 comments

    Supplemental Content

    Full text links

    Icon for HighWire
    Loading ...
    Support Center