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Pituitary. 2008;11(2):163-9. doi: 10.1007/s11102-008-0109-3.

Female hypogonadism: evaluation of the hypothalamic-pituitary-ovarian axis.

Author information

1
Department of Medicine, Division of Endocrinology, Anschutz Outpatient Pavilion, University of Colorado at Denver and Health Sciences Center, Aurora, CO 80045, USA. Micol.Rothman@uchsc.edu

Abstract

Female hypogonadism refers to deficient or abnormal function of the hypothalamic-pituitary-ovarian axis that clinically presents with menstrual cycle disturbances. Female hypogonadism can be due to a congenital or acquired cause, and the defect can be at the level of the hypothalamus, pituitary or ovary. A careful history, physical exam and selected laboratory testing can often determine the locus of the defect and whether it results from a structural or hormonal problem. Laboratory testing generally relies on basal hormone levels; however, timing of blood sampling in relation to menses is important to interpretation of the data.

PMID:
18404388
DOI:
10.1007/s11102-008-0109-3
[Indexed for MEDLINE]

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