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Chest. 2008 Aug;134(2):387-393. doi: 10.1378/chest.07-2207. Epub 2008 Apr 10.

FEV1 response to bronchodilation in an adult urban population.

Author information

1
Division of Pulmonary Medicine, Laboratory Department, Helsinki University Central Hospital, Helsinki, Finland.
2
Research Unit of Pulmonary Diseases, Laboratory Department, Helsinki University Central Hospital, Helsinki, Finland.
3
Department of Public Health, University of Helsinki, Helsinki, Finland.
4
Department of Medicine/Respiratory Medicine and Allergology, University of Gothenburg, Gothenburg, Sweden.
5
Division of Clinical Physiology and Nuclear Medicine, Laboratory Department, Helsinki University Central Hospital, Helsinki, Finland; Department of Medicine, and the Division of Clinical Physiology and Nuclear Medicine, Laboratory Department, Helsinki University Central Hospital, Helsinki, Finland.

Abstract

BACKGROUND:

Most studies evaluating bronchodilation in flow-volume spirometry have been conducted in patients with obstructive airways diseases, but less is known about bronchodilation responses in the general population or in healthy subjects.

METHODS:

We evaluated an urban population sample of 628 adults (260 men, 368 women) aged 25 to 74 years with flow-volume spirometry using inhalation of 0.4 mg of a salbutamol aerosol with a spacer device for bronchodilation. On the basis of a structured interview, a subgroup of 219 healthy, asymptomatic nonsmokers was selected.

RESULTS:

In the population sample, the average increase in FEV(1) from baseline after salbutamol inhalation was 77.2 mL (SD, 109.7 mL) or 2.5% (SD, 3.9%). In healthy asymptomatic nonsmokers, the mean change in FEV(1) was 62.0 mL (SD, 89.7 mL) or 1.8% (SD, 2.6%). In the whole population, the 95th percentile limit of the increase in FEV(1) was 8.5%, while it was 5.9% among healthy asymptomatic nonsmokers. The absolute change in FEV(1) correlated significantly with baseline FVC (p < 0.01). The FEV(1)/FVC ratio at baseline was the strongest influencing factor for the bronchodilation response.

CONCLUSIONS:

The results indicate that a significant increase in FEV(1) from baseline in a bronchodilation test is around 9% in an urban population. The level of the significant absolute increase in FEV(1) seems to depend on FVC. Low baseline FEV(1)/FVC ratio, reflecting airflow limitation, is the strongest determinant for FEV(1) response to bronchodilation.

PMID:
18403671
DOI:
10.1378/chest.07-2207
[Indexed for MEDLINE]

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