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Parkinsonism Relat Disord. 2009 Jan;15(1):24-9. doi: 10.1016/j.parkreldis.2008.02.007. Epub 2008 Apr 9.

Vascular pathology in patients with idiopathic Parkinson's disease.

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Movement Disorders Centre and Stroke Centre, First Department of Neurology, Masaryk University, St. Anne's Teaching Hospital, Pekarska 53, 656 91 Brno, Czech Republic.


To study the impact of brain vessel pathology on the clinical status of Parkinson's disease (PD), in 57 consecutive patients the clinical and neuropsychological data were compared with clinical MRI signs of vascular impairment and with the ultrasound brain vessel investigations. There was a significant correlation between clinical and cognitive status and intimomedial thickness, which is an indicator of large vessel impairment. Cognitive status was significantly related to the pulsatility index (an indicator of small vessel impairment). This study provides evidence that subclinical vascular pathology could influence the clinical status by contributing to motor and cognitive dysfunction in PD.

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