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Expert Rev Anticancer Ther. 2008 Apr;8(4):561-72. doi: 10.1586/14737140.8.4.561.

Immune cells in colorectal cancer: prognostic relevance and therapeutic strategies.

Author information

1
Institute of Molecular Medicine, University of Mainz, Mainz, Germany. imke.atreya@1-med.klinik.uni-mainz.de

Abstract

During the last two decades, considerable efforts have been made to improve the prevention, early diagnosis and therapy of colorectal cancer by gaining enhanced insights into disease-specific pathogenesis. Along these lines, tumor-infiltrating immune cells turned out to be critical indicators for an efficient antitumor immune response and the number and type of tumor-infiltrating immune cells determined the resulting tumor prognosis. This review aims to describe the prognostic relevance of the different subsets of tumor-infiltrating immune cells and highlights their specific function in the complex process of immune system-mediated rejection of colorectal cancer cells. Considering the clinical impact of this increased insight into tumor-associated immunology, resulting innovative approaches in the treatment of colorectal cancer are summarized and discussed immunotherapeutic critically.

PMID:
18402523
DOI:
10.1586/14737140.8.4.561
[Indexed for MEDLINE]

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