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Best Pract Res Clin Obstet Gynaecol. 2008 Jun;22(3):549-58. doi: 10.1016/j.bpobgyn.2008.02.001. Epub 2008 Apr 8.

Maternal morbidity and mortality in in-vitro fertilization.

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Centre for Reproduction Epidemiology, Tornblad Institute, University of Lund, Biskopsgatan 7, SE-223 62 Lund, Sweden.


Pregnancies following in-vitro fertilization (IVF) are known to be at increased risk of a number of pregnancy- and delivery-related complications when compared with non-IVF pregnancies. Most of these complications seem to be due to underlying fertility problems. Ovarian stimulation carries a marked risk for two serious conditions - ovarian torsion and ovarian hyperstimulation syndrome - both of which are relatively rare. Although some common pregnancy complications show an up to five times increased risk over non-IVF pregnancies, the absolute frequencies are still low for most of these conditions. However, an increased risk of placenta praevia might be to some extent due to the IVF procedure. No long-terms effects on cancer risk or mortality can be linked to the IVF procedure, although follow-up time is still relatively short.

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