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Bioorg Med Chem Lett. 2008 May 1;18(9):2930-4. doi: 10.1016/j.bmcl.2008.03.070. Epub 2008 Mar 29.

Novel 2-imidazoles as potent and selective alpha1A adrenoceptor partial agonists.

Author information

1
Department of Chemistry, Pfizer Global Research and Development, Sandwich Labs, Ramsgate Road, Sandwich, Kent CT13 9NJ, UK. gavin.whitlock@pfizer.com

Abstract

Novel 2-imidazoles have been identified as potent partial agonists of the alpha(1A) adrenergic receptor, with good selectivity over the alpha(1B), alpha(1D) and alpha(2A) receptor sub-types. Sulfonamide 23 possessed attractive drug-like properties with respect to physicochemical and ADME properties and wide ligand selectivity.

PMID:
18400496
DOI:
10.1016/j.bmcl.2008.03.070
[Indexed for MEDLINE]

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