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Prev Med. 2008 Jun;46(6):579-84. doi: 10.1016/j.ypmed.2008.02.026. Epub 2008 Mar 10.

High risk strategy in smoking cessation is feasible on a population-based level. The Inter99 study.

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Research Centre for Prevention and Health, The Capital Region of Denmark, Denmark.



A high risk strategy is one of more strategies in public health. Smoking remains the most important contributor to the burden of disease in developed countries.


A population-based multi-factorial intervention study, Inter99 (1999-2006), Copenhagen, Denmark, using a high risk strategy. All 2408 daily smokers were repeatedly offered individual face-to-face lifestyle counselling. Smokers in the high-intensity group were offered participation in smoking cessation groups. We measured point abstinence at 1, 3 and 5-year follow-up and compared with a control group, using adjusted intention-to treat analyses.


Compared with the control group it was twice as likely to be self-reported abstinent at 5-year follow-up in the high-intensity intervention group (OR: 2.19; 95%CI: 1.7-2.8; p<0.001). The effect of the intervention was significant, even when comparing validated abstinence in the intervention groups with self-reported abstinence in the control group (OR: 1.38; 95%CI: 1.1-1.8; p=0.014). Male gender, vocational training, higher age at onset of smoking, high knowledge of harm of smoking and lower tobacco consumption predicted abstinence.


A high risk strategy showed a significant effect on smoking in the long term. Proactive recruitment, face-to-face setting, repeated offer of assistance to quit and a multi-factorial approach may explain the success of the intervention.

[Indexed for MEDLINE]

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