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J Clin Psychiatry. 2008 May;69(5):844-53.

One-year course and predictors of outcome of adolescent depression: a case-control study in Finland.

Author information

1
Department of Mental Health and Alcohol Research, National Public Health Institute, Helsinki, Finland. linnea.karlsson@utu.fi

Abstract

BACKGROUND:

Clinical studies on the outcome of adolescent depression beyond treatment trials are scarce.

OBJECTIVE:

To investigate the impact of characteristics of the depressive episode and current comorbidity on the 1-year outcome of depression.

METHOD:

A sample of 174 consecutive adolescent psychiatric outpatients (aged 13 through 19 years) and 17 school-derived matched controls, all with unipolar depressive disorders at baseline, were reinterviewed for DSM-IV Axis I and Axis II disorders at 12 months. The study was conducted between January 1998 and May 2002.

RESULTS:

The outpatients had equal recovery rate and episode duration but shorter time to recurrence than the controls. Among the outpatients, Axis II comorbidity predicted shorter time to recurrence (p = .02). Longer time to recovery was predicted by earlier lifetime age at onset for depression (p = .02), poor psychosocial functioning (p = .003), depressive disorder diagnosis (p <or= .05), and longer episode duration by study entry (p = .001), with an interaction between episode duration and depressive disorder diagnosis (p = .04).

CONCLUSIONS:

Characteristics of depression generally predicted the outcome better than co-morbidity. Axis II comorbidity has prognostic value in adolescent depression.

PMID:
18399727
[Indexed for MEDLINE]

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