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Org Lett. 2008 May 1;10(9):1835-7. doi: 10.1021/ol800458k. Epub 2008 Apr 10.

Efficient synthesis of 2-(trifluoromethyl)nicotinic acid derivatives from simple fluorinated precursors.

Author information

1
BIAL-Portela and Ca, Trofa, Portugal.

Abstract

Novel routes to 2-trifluoromethyl-nicotinic acid derivatives have been developed involving synthesis of the pyridine ring. These pyridyl compounds serve as key intermediates in the manufacture of the recently discovered COMT inhibitor, 3-(5-(3,4-dihydroxy-5-nitrophenyl)-1,2,4-oxadiazol-3-yl)-2-(trifluoromethyl)pyridine 1-oxide.

PMID:
18399636
DOI:
10.1021/ol800458k
[Indexed for MEDLINE]

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