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Curr Opin Cell Biol. 1991 Dec;3(6):1019-24.

Protein synthesis, cell growth and oncogenesis.

Author information

1
University of Kentucky, Lexington.

Abstract

Two lines of investigation support a new hypothesis concerning the role of protein synthesis in the mitogenic pathway. The first is that a variety of mitogens and oncogene products increase phosphorylation and thereby activate eIF-4E, which is involved in the rate-limiting transfer of mRNA to ribosomes. The second is that overexpression or microinjection of eIF-4E induce rapid cell proliferation and oncogenic transformation.

PMID:
1839953
DOI:
10.1016/0955-0674(91)90123-g
[Indexed for MEDLINE]

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