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Curr Eye Res. 2008 Apr;33(4):325-32. doi: 10.1080/02713680802011679.

Is there a relationship between blood pressure and intraocular pressure? An experimental study in hypertensive rats.

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1
Institute of Biomedicine, Pharmacology, University of Helsinki, Finland.

Abstract

PURPOSE:

Evaluation of relation between blood pressure (BP) and intraocular pressure (IOP) in two hypertensive rat strains: spontaneously hypertensive rats (SHR) and double transgenic (dTGR) (harboring human renin and angiotensinogen genes) rats, and in their normotensive control Wistar Kyoto and Sprague Dawley rats, respectively.

METHODS:

Each rat strain was divided into medicated and non-medicated groups. Medicated rats were treated orally with an angiotensin II receptor type 1 blocker. IOP was measured using a specific rebound tonometer and BP by a tail-cuff method. Both parameters were determined in conscious animals every second week. For comparison, at the end of the study, IOP was measured in conscious and anesthetized rats.

RESULTS:

The baseline IOP was higher in hypertensive rats vs their normotensive controls. Eight weeks of treatment with an angiotensin type 1 receptor blocker did not prevent a slight increase in IOP, although it abolished the development of hypertension in SHR. The markedly elevated IOP was reduced in medicated and non-medicated dTGR animals during the short follow-up period. General anesthesia reduced IOP significantly.

CONCLUSION:

The results suggest a positive relation between BP and IOP in hypertensive rats.

PMID:
18398707
DOI:
10.1080/02713680802011679
[Indexed for MEDLINE]
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