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Curr Eye Res. 2008 Apr;33(4):303-12. doi: 10.1080/02713680801971857.

In vitro effects of preservative-free tafluprost and preserved latanoprost, travoprost, and bimatoprost in a conjunctival epithelial cell line.

Author information

1
Department of Ophthalmology III, Quinze-Vingts National Ophthalmology Hospital, Paris, France.

Abstract

PURPOSE:

This study compared the toxicity profiles of three antiglaucoma prostaglandin F2alpha analogs, latanoprost, travoprost, and bimatoprost which contain benzalkonium chloride (BAK), with tafluprost, a new preservative-free prostaglandin analog.

METHODS:

IOBA-NHC cells were exposed to BAK-containing prostanoid solutions, their respective BAK concentrations, and preservative-free tafluprost solution for 30 min. Membrane integrity, apoptosis, oxidative stress, and cells morphology were evaluated.

RESULTS:

Preservative-free tafluprost resulted in significantly higher membrane integrity and lower pro-apoptotic and pro-oxidative effects than preservative-containing prostaglandin analog preparations.

CONCLUSIONS:

These results suggest that tafluprost, a new preservative-free prostaglandin analog, has very low or no pro-apoptotic, pro-necrotic, or pro-oxidative effects in vitro compared to preservative-containing formulations.

PMID:
18398704
DOI:
10.1080/02713680801971857
[Indexed for MEDLINE]

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