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Dalton Trans. 2008 Apr 28;(16):2107-10. doi: 10.1039/b802806k. Epub 2008 Mar 18.

Cellular confocal fluorescence studies and cytotoxic activity of new Zn(II) bis(thiosemicarbazonato) complexes.

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1
Chemistry Department, University of Bath, Claverton Down, UKBA2 7AY. s.pascu@bath.ac.uk

Abstract

We report the synthesis and characterisation of new, highly fluorescent, zinc complexes of bis(thiosemicarbazone) ligands incorporating extended aromatic backbones which are cytotoxic at levels comparable to cisplatin; cellular fluorescence imaging studies suggest these cause cell death by disruption of mitochondria.

PMID:
18398535
DOI:
10.1039/b802806k
[Indexed for MEDLINE]
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