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J Clin Endocrinol Metab. 2008 Jun;93(6):2350-7. doi: 10.1210/jc.2007-2057. Epub 2008 Apr 8.

Leptin and ghrelin in relation to Helicobacter pylori status in adult males.

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1
New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA.

Abstract

CONTEXT:

Leptin and ghrelin, hormones involved in human energy homeostasis, are both produced in the stomach.

OBJECTIVE:

We sought to determine whether the presence of Helicobacter pylori affects gastric and systemic levels of leptin and ghrelin.

DESIGN, SETTING, AND PATIENTS:

We consecutively enrolled 256 patients referred for upper endoscopy at a Veterans Affairs outpatient endoscopy center.

OUTCOMES:

We obtained fasting serum, fundic and antral biopsies, and gastric juice. Based on histological, biochemical, and serological assays, patients were categorized as H. pylori+ or H. pylori-. Leptin and total ghrelin levels in serum, gastric biopsies, and gastric juice were determined by specific ELISAs.

RESULTS:

Of the 256 subjects, 120 were H. pylori+ and 96 were H. pylori-; 40 patients of indeterminate status were excluded. Serum and fundic leptin levels correlated with body mass index in the H. pylori+ (r = 0.35; P < 0.0001 and r = 0.35; P < 0.0001, respectively) and H. pylori- (r = 0.65; P < 0.0001 and r = 0.41; P < 0.0001, respectively) groups, but H. pylori+ subjects had significantly lower serum leptin levels [median 2.2 ng/ml (interquartile range 0.9-4.6) vs. 4.0 ng/ml (1.7-7.2); P = 0.0003]. Serum ghrelin levels were similar in the H. pylori+ and H. pylori- groups [median 1651 pg/ml (interquartile range 845-2247) vs. 1629 pg/ml (992-2886); P = 0.23]. H. pylori status did not significantly affect gastric biopsy leptin and ghrelin levels. Ghrelin levels in gastric juice varied over 4 log(10) (<80-776,000 pg/ml) and correlated with gastric juice pH in the H. pylori+ group (r = 0.68; P < 0.0001).

CONCLUSIONS:

These findings provide evidence that H. pylori status affects leptin and ghrelin homeostasis, presumably via intragastric interactions.

PMID:
18397989
PMCID:
PMC2435636
DOI:
10.1210/jc.2007-2057
[Indexed for MEDLINE]
Free PMC Article

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