Format

Send to

Choose Destination
See comment in PubMed Commons below
Ugeskr Laeger. 2008 Mar 10;170(11):929-33.

[Mutations in the heart's pacemaker channels--a new cause of sick sinus node syndrome and long-QT syndrome].

[Article in Danish]

Author information

1
Statens Serum Institut, Klinisk Biokemisk Afdeling, Markørlaboratoriet, DK-2300 København S.

Abstract

The sinus node hyperpolarization-activated If current generated by the cardiac pacemaker channels HCN2 and HCN4 determines the autonomous beating of the heart. Cardiac arrhythmias, like long-QT syndrome, are often caused by irregularities of the heart action potential generated by mutations in cardiac ion channel genes. Mutations in the HCN4 gene have been associated with sick sinus syndrome and long-QT syndrome. The identification of cardiac arrhythmia disease-associated genes makes possible new therapeutic strategies based on gene-specific drug treatment and gene therapy.

PMID:
18397618
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Loading ...
    Support Center