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Curr Opin Microbiol. 2008 Apr;11(2):153-60. doi: 10.1016/j.mib.2008.02.013. Epub 2008 Apr 8.

Nutritional control via Tor signaling in Saccharomyces cerevisiae.

Author information

1
Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Room 1078, 600 University Avenue, Toronto, ON M5G 1X5, Canada.

Abstract

The yeast Saccharomyces cerevisiae senses and responds to nutrients by adapting its growth rate and undergoing morphogenic transitions to ensure survival. The Tor pathway is a major integrator of nutrient-derived signals that in coordination with other signaling pathways orchestrates cell growth. Recent advances have identified novel Tor kinase substrates and established the protein trafficking membranous network and the nucleus as platforms for Tor signaling. These and other recent findings delineate distinct signaling branches emanating from membrane-associated Tor complexes to control cell growth.

PMID:
18396450
PMCID:
PMC2394285
DOI:
10.1016/j.mib.2008.02.013
[Indexed for MEDLINE]
Free PMC Article

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