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Med Image Anal. 2008 Aug;12(4):484-96. doi: 10.1016/ Epub 2008 Feb 15.

Regions, systems, and the brain: hierarchical measures of functional integration in fMRI.

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Inserm, U678, Paris F-75013, France.


In neuroscience, the notion has emerged that the brain abides by two principles: segregation and integration. Segregation into functionally specialized systems and integration of information flow across systems are basic principles that are thought to shape the functional architecture of the brain. A measure called integration, originating from information theory and derived from mutual information, has been proposed to characterize the global integrative state of a network. In this paper, we show that integration can be applied in a hierarchical fashion to quantify functional interactions between compound systems, each system being composed of several regions. We apply this method to fMRI datasets from patients with low-grade glioma and show how it can efficiently extract information related to both intra- and interhemispheric reorganization induced by lesional brain plasticity.

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