Format

Send to

Choose Destination
Eur J Vasc Endovasc Surg. 2008 Jul;36(1):71-6. doi: 10.1016/j.ejvs.2008.01.029. Epub 2008 Apr 18.

The association of peripheral arterial occlusive disease with major coronary events in a mediterranean population with low coronary heart disease incidence.

Author information

1
Angiology and Vascular Surgery, Hospital del Mar, Universidad Autonoma Barcelona, Barcelona, Spain.

Abstract

OBJECTIVES:

The association of peripheral arterial occlusive disease (PAD) association with major coronary events (MCE) has been well documented, nevertheless data are lacking for populations with a low incidence of coronary heart disease (CHD). We aimed to assess the association of PAD with MCE in a Mediterranean population.

DESIGN:

Prospective survey of 699 55-74 year-old men representative of an urban district near Barcelona (Spain).

METHODS:

Baseline cardiovascular risk factors, CHD and PAD (ankle/brachial index<0.9) were recorded. MCE were evaluated during the 5-year follow-up.

RESULTS:

At recruitment 94 subjects (13.4%) had PAD. During follow-up (mean 69.3 months), 35 (5%) subjects suffered a MCE, of whom 12 had PAD, 9 previous symptomatic CHD and 1 subject both conditions. Higher CHD related mortality (8.6% vs 1.4%; p<0.001) and lower MCE-free survival (78.67% vs 93.26%; p<0.001) was observed for PAD subjects. On Cox regression analysis PAD (RR=3; p=0.003) and previous symptomatic CHD (RR=4.1; p<0.001) were associated independently with MCE during follow-up.

CONCLUSIONS:

Even in a population with a low incidence of CHD there is a strong relationship between PAD and future MCE. Screening for PAD may improve the selection of patients targeted for cardiovascular risk prevention.

PMID:
18396072
DOI:
10.1016/j.ejvs.2008.01.029
[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center