Format

Send to

Choose Destination
Eur J Immunol. 2008 Apr;38(4):931-4. doi: 10.1002/eji.200738108.

Clinical application of regulatory T cells for treatment of type 1 diabetes and transplantation.

Author information

1
UCSF Diabetes Center, University of California, San Francisco, San Francisco, CA 941430540, USA.

Abstract

Immune regulation is a complex process that depends on the maintenance of self tolerance while retaining robust immune responses against microbes. The emergence of Treg as a central mechanism for immune regulation has generated a new paradigm where Treg-resistant memory T cells and/or "defective" Treg lead to a breakdown in tolerance resulting in immune pathology. In this perspective, we highlight the opportunities and challenges in the field of Treg therapy.

PMID:
18395864
DOI:
10.1002/eji.200738108
[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for Wiley
Loading ...
Support Center