Format

Send to

Choose Destination
Eur J Immunol. 2008 Apr;38(4):918-21. doi: 10.1002/eji.200738120.

Role of Foxp3-positive regulatory T cells during infection.

Author information

1
Mucosal Immunology Unit, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. ybelkaid@niaid.nih.gov

Abstract

Surviving an infection requires the generation of an immune response that controls the invading pathogen while limiting collateral damage to self tissues that may result from an exuberant immune response. Various populations of regulatory cells, including Foxp3+ Treg, have been shown to play a central role in the establishment of these controlled immune responses. In this review, I discuss current hypotheses and points of polemic associated with the origin, mode of action and antigen specificity of Foxp3+ Treg during infection.

PMID:
18395860
PMCID:
PMC4052573
DOI:
10.1002/eji.200738120
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Wiley Icon for PubMed Central
Loading ...
Support Center