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Eur J Immunol. 2008 Apr;38(4):915-7. doi: 10.1002/eji.200738111.

The critical contribution of TGF-beta to the induction of Foxp3 expression and regulatory T cell function.

Author information

1
Laboratory of Immunology, NIAID, NIH, Bethesda, MD 20892, USA. EShevach@niaid.nih.gov

Abstract

Stimulation of mouse CD4+ T cells in the presence of TGF-beta results in the expression of Foxp3 and induction of Treg function. Stimulation of human CD4+ T cells under similar conditions results in the expression of Foxp3, but the cells lack regulatory cell function. TGF-beta expressed on the surface of Treg also induces Foxp3 expression and Treg function in responder cells. Both of these mechanisms may play a role in vivo in the induction of antigen-specific extra-thymic Treg.

PMID:
18395859
PMCID:
PMC2662375
DOI:
10.1002/eji.200738111
[Indexed for MEDLINE]
Free PMC Article

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