Format

Send to

Choose Destination
Eur J Immunol. 2008 Apr;38(4):908-11. doi: 10.1002/eji.200738114.

How many mechanisms do regulatory T cells need?

Author information

1
Department of Immunology, St. Jude Children's Research Hospital, 332 N Lauderdale, Memphis, TN 38105-2794, USA. dario.vignali@stjude.org

Abstract

A plethora of new regulatory T cell (Treg) mechanisms have recently emerged. This raises two important questions. First, how many molecules or mechanisms are required for Treg to work? Second, how should we evaluate the contribution of any given Treg molecule/mechanism and how is this likely to relate (or not) to the phenotype seen in Scurfy/Foxp3-deficient mice? In this discussion piece, I will briefly outline our current understanding of the Treg arsenal and address these important questions.

PMID:
18395857
DOI:
10.1002/eji.200738114
[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for Wiley
Loading ...
Support Center