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Am J Obstet Gynecol. 2008 Jun;198(6):635.e1-6. doi: 10.1016/j.ajog.2008.01.062. Epub 2008 Apr 8.

Clostridium difficile-associated diarrhea: an emerging threat to pregnant women.

Author information

1
Division of Bacterial Diseases, Epidemic Intelligence Service Field Assignments Branch,Centers for Disease Control and Prevention, Atlanta, GA, USA.

Abstract

OBJECTIVE:

To estimate if Clostridium difficile-associated disease (CDAD) is increasing in peripartum women.

STUDY DESIGN:

Peripartum CDAD was assessed through 1) passive surveillance collecting clinical and pathology data on severe cases and 2) survey among infectious disease consultants (ICDs) in the Emerging Infections Network.

RESULTS:

Ten severe cases were collected; most had associated antibiotic use. Seven women were either admitted to the ICU or underwent colectomy. Three infants were stillborn, and 3 women died. The epidemic Clostridium difficile strain was found in 2 cases. Among 798 ICDs, 419 (52%) participated in the survey. Thirty-seven respondents (9%) recalled 55 cases, mostly in the postpartum period with 21 complications, mainly due to relapse.

CONCLUSION:

Severe CDAD may be increasing in peripartum women. Clinicians should have a low threshold for testing, be aware of the potential for severe outcomes, and take steps to reduce both the risk of disease and resultant complications.

PMID:
18395693
DOI:
10.1016/j.ajog.2008.01.062
[Indexed for MEDLINE]

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