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Vaccine. 2008 Apr 24;26(18):2186-90. doi: 10.1016/j.vaccine.2008.01.059. Epub 2008 Mar 17.

Superiority of needle-free transdermal plasmid delivery for the induction of antigen-specific IFNgamma T cell responses in the dog.

Author information

1
Merial S.A.S., R&D, Laboratoire de Lyon Gerland, Lyon, France.

Abstract

Although successful needle-free DNA vaccination has been described on several occasions, the true benefit of this delivery technology over needle-based injections for DNA vaccination of dogs has not yet been documented. We conducted a side-by-side comparison of needle-free transdermal plasmid delivery vs. intramuscular vs. intradermal needle-based delivery of the same plasmid in dogs. Our data confirmed the importance of the route of plasmid delivery and further established the unique potential of needle-free transdermal plasmid delivery to elicit strong antigen-specific, hTyr-specific IFNgamma T in the dog. Further, this study demonstrated that properly enabled DNA vaccination has the potential to trigger very significant cell-based immune responses in dogs, establishing needle-free transdermal plasmid delivery as a critical technology for successful immunotherapy of cancer and/or chronic infectious diseases in companion animal medicine.

PMID:
18395307
DOI:
10.1016/j.vaccine.2008.01.059
[Indexed for MEDLINE]

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