Format

Send to

Choose Destination
See comment in PubMed Commons below
Behav Brain Res. 2008 Sep 1;192(1):12-9. doi: 10.1016/j.bbr.2008.02.033. Epub 2008 Feb 26.

A role for the spine apparatus in LTP and spatial learning.

Author information

1
Institute of Clinical Neuroanatomy, J.W. Goethe-University of Frankfurt, Theodor-Stern-Kai 7, Frankfurt am Main, Germany.

Abstract

Long-term potentiation (LTP) of synaptic strength is a long-lasting form of synaptic plasticity that has been linked to information storage. Although the molecular and cellular events underlying LTP are not yet fully understood, it is generally accepted that changes in dendritic spine calcium levels as well as local protein synthesis play a central role. These two processes may be influenced by the presence of a spine apparatus, a distinct neuronal organelle found in a subpopulation of telencephalic spines. Mice lacking spine apparatuses (synaptopodin-deficient mice) show deficits in LTP and impaired spatial learning supporting the involvement of the spine apparatus in synaptic plasticity. In our review, we consider the possible roles of the spine apparatus in LTP1 (protein synthesis-independent), LTP2 (translation-dependent and transcription-independent) and LTP3 (translation- and transcription-dependent) and discuss the effects of the spine apparatus on learning and memory.

PMID:
18395274
DOI:
10.1016/j.bbr.2008.02.033
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center