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Fertil Steril. 2009 May;91(5):1903-8. doi: 10.1016/j.fertnstert.2008.01.090. Epub 2008 Apr 3.

Tumor necrosis factor alpha and lymphotoxin alpha haplotypes in idiopathic recurrent pregnancy loss.

Author information

1
Faculty of Pharmacy, Research Unit of Hematologic and Autoimmune Diseases, University of Monastir, Monastir, Tunisia.

Abstract

OBJECTIVE:

To investigate the contribution of the -238G/A and -308G/A tumor necrosis factor (TNF) alpha, and +252A/G lymphotoxin (LT) alpha gene polymorphisms to idiopathic recurrent miscarriage (RM).

DESIGN:

A retrospective case-control study.

SETTING:

Outpatient maternity center.

PATIENT(S):

Study subjects comprised 372 RM women and 274 age-matched parous control women.

INTERVENTION(S):

None.

MAIN OUTCOME MEASURE(S):

The TNFalpha and LTalpha gene variants and idiopathic RM.

RESULT(S):

Higher prevalence of TNFalpha -238A and LTalpha +252G alleles and LTalpha +252G/G genotype and lower frequencies of TNFalpha -308G/A were seen in RM cases. Three-loci haplotype analysis (TNFalpha -308GA/TNFalpha -238GA/LTalpha +252AG) demonstrated significant association between TNFalpha-LTalpha gene variants and RM. Both protective [-308A/-238G/+252A], and susceptible [-308G/-238A/+252G] haplotypes were identified. Mutlivariate regression analysis confirmed the association of -308G/-238A/+252G haplotype with exclusively early RM, after controlling for a number of covariates; no specific TNFalpha and LTalpha genotypes or haplotypes were linked with either late or combined early and late RM.

CONCLUSION(S):

The TNFalpha -238G/A and LTalpha +252A/G, but not TNFalpha -308G/A, polymorphic variants are associated with exclusively early idiopathic RM.

[Indexed for MEDLINE]

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