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Prog Brain Res. 2008;169:97-115. doi: 10.1016/S0079-6123(07)00006-4.

Regulation of hippocampus-dependent memory by cyclic AMP-dependent protein kinase.

Author information

1
University of Pennsylvania, Department of Biology, Biological Basis of Behavior Program, Philadelphia, PA 19104, USA.

Abstract

The hippocampus is crucial for the consolidation of new declarative long-term memories. Genetic and behavioral experimentation have revealed that several protein kinases are critical for the formation of hippocampus-dependent long-term memories. Cyclic-AMP dependent protein kinase (PKA) is a serine-threonine kinase that has been strongly implicated in the expression of specific forms of hippocampus-dependent memory. We review evidence that PKA is required for hippocampus-dependent memory in mammals, and we highlight some of the proteins that have been implicated as targets of PKA. Future directions and open questions regarding the role of PKA in memory storage are also described.

PMID:
18394470
PMCID:
PMC2914307
DOI:
10.1016/S0079-6123(07)00006-4
[Indexed for MEDLINE]
Free PMC Article

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