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Nat Rev Microbiol. 2008 May;6(5):387-94. doi: 10.1038/nrmicro1889.

Genomic fluidity and pathogenic bacteria: applications in diagnostics, epidemiology and intervention.

Author information

1
Pathogen Evolution Laboratory, Center for DNA Fingerprinting and Diagnostics, Nacharam, Hyderabad 500076, India.

Abstract

The increasing availability of DNA-sequence information for multiple pathogenic and non-pathogenic variants of individual bacterial species has indicated that both DNA acquisition and genome reduction have important roles in genome evolution. Such genomic fluidity, which is found in human pathogens such as Escherichia coli, Helicobacter pylori and Mycobacterium tuberculosis, has important consequences for the clinical management of the diseases that are caused by these pathogens and for the development of diagnostics and new molecular epidemiological methods.

PMID:
18392032
DOI:
10.1038/nrmicro1889
[Indexed for MEDLINE]

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