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Nat Med. 2008 May;14(5):507-9. doi: 10.1038/nm1752. Epub 2008 Apr 6.

Dopamine neurons implanted into people with Parkinson's disease survive without pathology for 14 years.

Author information

1
Dalhousie University and Queen Elizabeth II Health Sciences Centre, Division of Neurosurgery and Department of Anatomy & Neurobiology, 1976 Summer Street, Halifax, Nova Scotia B3H 3A7, Canada.

Abstract

Postmortem analysis of five subjects with Parkinson's disease 9-14 years after transplantation of fetal midbrain cell suspensions revealed surviving grafts that included dopamine and serotonin neurons without pathology. These findings are important for the understanding of the etiopathogenesis of midbrain dopamine neuron degeneration and future use of cell replacement therapies.

PMID:
18391961
PMCID:
PMC2656682
DOI:
10.1038/nm1752
[Indexed for MEDLINE]
Free PMC Article

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