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Nat Neurosci. 2008 May;11(5):538-40. doi: 10.1038/nn.2104. Epub 2008 Apr 6.

Silencing preBötzinger complex somatostatin-expressing neurons induces persistent apnea in awake rat.

Author information

1
Department of Neurobiology, Box 951763, David Geffen School of Medicine at University of California Los Angeles, 650 Charles E. Young Dr. South, Los Angeles, California 90095, USA.

Abstract

Delineating neurons that underlie complex behaviors is of fundamental interest. Using adeno-associated virus 2, we expressed the Drosophila allatostatin receptor in somatostatin (Sst)-expressing neurons in the preBötzinger Complex (preBötC). Rapid silencing of these neurons in awake rats induced a persistent apnea without any respiratory movements to rescue their breathing. We hypothesize that breathing requires preBötC Sst neurons and that their sudden depression can lead to serious, even fatal, respiratory failure.

PMID:
18391943
PMCID:
PMC2515565
DOI:
10.1038/nn.2104
[Indexed for MEDLINE]
Free PMC Article

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