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Nat Prod Rep. 2008 Apr;25(2):318-41. doi: 10.1039/b705652b. Epub 2008 Feb 11.

Recent advances in the total synthesis of pharmaceutically relevant diterpenes.

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  • 1Institut für Organische Chemie und Zentrum für Biomolekulare Wirkstoffchemie (BMWZ), Leibniz Universität Hannover, Schneiderberg 1B, Hannover, D-30167, Germany.

Abstract

A detailed overview is presented of recent total synthesis approaches to four different diterpenoids--the ginkgolides, tonantzitlolone, ingenol and eleutherobin. Due to their structural complexity, all pose major challenges for total synthesis, guaranteeing diverse strategic tours de force and a rich synthetic chemistry. Additionally, all four diterpenoids are of major relevance because of their biological (target) or pharmaceutical properties.

PMID:
18389140
DOI:
10.1039/b705652b
[PubMed - indexed for MEDLINE]
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