Send to

Choose Destination
See comment in PubMed Commons below
Drugs Today (Barc). 2008 Feb;44(2):147-68. doi: 10.1358/dot.2008.44.2.1191059.

An evidence-based review updating the various treatment and management approaches to serotonin reuptake inhibitor-associated sexual dysfunction.

Author information

  • 1Department of Psychiatry, Health Sciences Center, University of New Mexico School of Medicine, Albuquerque, New Mexico 87131-52886, USA.


Although most patients (80-90%) will respond to the first or second antidepressant prescribed, major depression disease management outcomes data are poor. Serotonin reuptake inhibitor (SRI) antidepressant-associated sexual dysfunction, which is reported to occur in 40-70% of patients on these agents, is a major factor for treatment noncompliance, treatment failure and costly disease management outcomes. Up to 90% of patients with treatment-emergent sexual dysfunction will discontinue their prescribed medication prematurely. Despite several thousand published reports on treatment modalities based on heuristic post hoc hypotheses of central serotonin inhibition and those involving agonist, antagonist, partial agonist, switching, augmentation and waiting management approaches, no evidence-based data are available to support those treatment modalities, leaving patients exposed to random pharmacology. The emergence of new approaches based on novel signaling to treat sexual dysfunction, which demonstrate efficacy for selective type 5 phosphodiesterase inhibitor treatment of SRI antidepressant-associated sexual dysfunction, offers an opportunity for an evidence-based re-evaluation of the comparative effectiveness of various management approaches to SRI antidepressant-associated sexual dysfunction.

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Prous Science
    Loading ...
    Support Center