Health literacy--the ability to read, understand, and use health information to make health care decisions--affects health care outcomes, hospitalization costs, and readmission. The purpose of this exploratory mixed-methods study is to determine how two different parent groups (English speaking and Spanish speaking) understand medical care for their children and the procedural and research consent forms required by that care. Quantitative and qualitative data are gathered and compared concurrently. Differences between groups are found in age, grade completed, Short Test of Functional Health Literacy in Adults scores, and ways of understanding health information. Identifying how parents understand health information is the first step in providing effective family-centered health care education.