Format

Send to

Choose Destination
Cell Signal. 2008 Sep;20(9):1579-91. doi: 10.1016/j.cellsig.2008.02.003. Epub 2008 Feb 15.

To (TGF)beta or not to (TGF)beta: fine-tuning of Smad signaling via post-translational modifications.

Author information

1
Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX 77030, USA.

Abstract

Smad proteins are key signal transducers for the TGF-beta superfamily and are frequently inactivated in human cancers, yet the molecular basis of how their levels and activities are regulated remains unclear. Recent progress, discussed herein, illustrates the critical roles of Smad post-translational modifications in the cellular outcome to TGF-beta signaling.

PMID:
18387785
PMCID:
PMC2597537
DOI:
10.1016/j.cellsig.2008.02.003
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Elsevier Science Icon for PubMed Central
Loading ...
Support Center