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Cancer Causes Control. 2008 Oct;19(8):887-94. doi: 10.1007/s10552-008-9151-8. Epub 2008 Apr 2.

Cancer risk in a cohort of patients with systemic lupus erythematosus (SLE) in California.

Author information

1
California Cancer Registry, Public Health Institute, 1700 Tribute Road, Suite100, Sacramento, CA 95815-4402, USA. aparikh@ccr.ca.gov

Abstract

OBJECTIVE:

We conducted a retrospective cohort study to examine cancer risk in a large cohort of systemic lupus erythematosus (SLE) patients in California.

METHODS:

The cohort consisted of individuals with SLE derived from statewide patient discharge data during the period 1991-2002. SLE patients were followed using cancer registry data to examine patterns of cancer development. Standardized incidence ratios (SIRs) and 95% CI were calculated to compare the observed to expected numbers of cancers based on age-, race-, and sex-specific incidence rates in the California population.

RESULTS:

The 30,478 SLE patients were observed for 157,969 person-years. A total of 1,273 cancers occurred within the observation interval. Overall cancer risk was significantly elevated (SIR = 1.14, 95% CI = 1.07-1.20). SLE patients had higher risks of vagina/vulva (SIR = 3.27, 95% CI = 2.41-4.31) and liver cancers (SIR = 2.70, 95% CI = 1.54-4.24). Elevated risks of lung, kidney, and thyroid cancers and several hematopoietic malignancies were also observed. Individuals had significantly lower risks of several screenable cancers, including breast, cervix, and prostate.

CONCLUSIONS:

These data suggest that risks of several cancer types are elevated among SLE patients. Detailed studies of endogenous and exogenous factors that drive these associations are needed.

Comment in

PMID:
18386139
PMCID:
PMC4357418
DOI:
10.1007/s10552-008-9151-8
[Indexed for MEDLINE]
Free PMC Article

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